ASSISTANT Professor

STEVEN BLOOM

RESEARCH OVERVIEW

Photoredox catalysis has emerged as an attractive tool for medicinal chemistry, streamlining both targeted drug synthesis and late-stage molecular editing. Research in the Bloom group seeks to harness this multifarious platform to address key challenges at the interface of synthetic chemistry and biotechnology.

Specifically, our group is interested in the use of photoredox catalysis for the synthesis of peptide and protein-based therapeutics. Among our current interests are the development of chemical methods for the controlled synthesis of non-classical peptides, peptibodies, fusion proteins, bispecific antibody constructs, and peptide/protein-based drug conjugates for use in targeted therapy.

 

Photoredox catalysis, peptide therapeutics, biologics, targets, drug discovery, Pharma, Pharma, Bloom, Steve Bloom, The Bloom Group, KU, Science, Peptides, research, unnatural amino acids, peptide libraries, biocompatible photocatalysts, tethering biomolecules, chemotherapeutics, photochemical strategies, fusion proteins, antibody conjugates, bi-specific peptides, light activated molecules, electron oxidation, synthetic radical intermediates, therapeutic scaffolds, medicinally relevant compounds, bio-derived therapeutics, small cell lung cancer, viral capsid, improved therapeutics,
Photoredox catalysis, peptide therapeutics, biologics, targets, drug discovery, Pharma, Pharma, Bloom, Steve Bloom, The Bloom Group, KU, Science, Peptides, research, unnatural amino acids, peptide libraries, biocompatible photocatalysts, tethering biomolecules, chemotherapeutics, photochemical strategies, fusion proteins, antibody conjugates, bi-specific peptides, light activated molecules, electron oxidation, synthetic radical intermediates, therapeutic scaffolds, medicinally relevant compounds, bio-derived therapeutics, small cell lung cancer, viral capsid, improved therapeutics,

STEVEN BLOOM

EDUCATION

lightbulbmenu

2015-2018

Postdoctoral

Department of Chemistry, Princeton University, Princeton, NJ (Advisor: David W. C. MacMillan). 

2015-2018
lightbulbmenu

2012-2015

PH.D.

Organic Chemistry, Department of Chemistry, Johns Hopkins University, Baltimore, MD (Advisor: Thomas Lectka). 

2012-2015
lightbulbmenu

2010

B.A., Chemistry and Biochemistry

McDaniel College, Westminster, MD

2010
Photoredox catalysis, peptide therapeutics, biologics, targets, drug discovery, Pharma, Pharma, Bloom, Steve Bloom, The Bloom Group, KU, Science, Peptides, research, unnatural amino acids, peptide libraries, biocompatible photocatalysts, tethering biomolecules, chemotherapeutics, photochemical strategies, fusion proteins, antibody conjugates, bi-specific peptides, light activated molecules, electron oxidation, synthetic radical intermediates, therapeutic scaffolds, medicinally relevant compounds, bio-derived therapeutics, small cell lung cancer, viral capsid, improved therapeutics,

STEVEN BLOOM

AWARDS & HONORS

lightbulbmenu

2016-Present

Postdoctoral fellowship

National Institute of Health Ruth L. Kirschstein Fellowship

2016-Present
lightbulbmenu

2015-2016

Postdoctoral Fellowship

Bristol Myers Squibb Postdoctoral Fellowship (BMS-CMS)

2015-2016
lightbulbmenu

2013

Fellowship

Owens Fellowship

2013
lightbulbmenu

2012

Fellowship

Gary H. Posner Fellowship

2012
lightbulbmenu

2010

McDaniel College

Graduated with honors in chemistry and biochemistry from McDaniel College

2010
Photoredox catalysis, peptide therapeutics, biologics, targets, drug discovery, Pharma, Pharma, Bloom, Steve Bloom, The Bloom Group, KU, Science, Peptides, research, unnatural amino acids, peptide libraries, biocompatible photocatalysts, tethering biomolecules, chemotherapeutics, photochemical strategies, fusion proteins, antibody conjugates, bi-specific peptides, light activated molecules, electron oxidation, synthetic radical intermediates, therapeutic scaffolds, medicinally relevant compounds, bio-derived therapeutics, small cell lung cancer, viral capsid, improved therapeutics,

STEVEN BLOOM

PUBLICATIONS

lightbulbmenu

2018

DECARBOXYLATIVE ALKYLATION FOR SITE-SELECTIVE BIOCONJUGATION OF NATIVE PROTEINS VIA OXIDATION POTENTIALS.

NAT. CHEM.

Bloom, S.; Liu, C.; Kolmel, D. K.; Qiao, J. X.; Zhang, Y.; Poss, M. A.; Ewing, W. R.; MacMillan, D. W. C.

2018, 10, 205-211.

2018
lightbulbmenu

2015

Site-Selective Approach to b-Fluorination: Photocatalyzed Ring Opening of Cyclopropanols.

CHEM. EUR. J.

Bloom, S.; Blume, D.; Pitts, C. R.; Lectka, T. 

2015, 21, 8060-8063.

2015
lightbulbmenu

2014

Photocatalyzed Benzylic Fluorination: Shedding “Light” on the Involvement of Electron Transfer.

ORG. LETT.

Bloom, S.; McCann, M.; Lectka, T. 

2014, 16, 6338-6341.

2014
lightbulbmenu

2014

A Chelating Nucleophile Plays a Starring Role: 1,8-Naphthyridine-Catalyzed Polycomponent a,a-Difluorination of Acid Chlorides.

J. ORG. CHEM.

Griswold, A.; Bloom, S.; Lectka, T.

2014, 79, 9830-9834.

2014
lightbulbmenu

2014

A Cooperative Allylic Fluorination: Combination of Nucleophilic and Electrophilic Fluorine Sources.

TETRAHEDRON LETT.

Bloom, S.; Knippel, J. L.; Holl, M. G.; Barber, R.; Lectka, T. 

2014, 55, 4576-4580.

2014
lightbulbmenu

2014

Direct, Catalytic, Monofluorination of sp3 C-H Bonds: A Radical-Based Mechanism with Ionic Selectivity.

J. AM. CHEM. SOC.

Pitts, C. R.; Bloom, S.; Woltornist, R.; Auvenshine, D.; Ryzhkov, L. R.; Siegler, M. A.; Lectka, T.

2014, 136, 9780-9791.

2014
lightbulbmenu

2014

A Photocatalyzed Aliphatic Fluorination.

CHEM. SCI.

Bloom, S.; Knippel, J. L.; Lectka, T.

2014, 5, 1175-1178.

2014
lightbulbmenu

2013

Metal-Catalyzed Benzylic Fluorination as a Synthetic Equivalent to 1,4-Conjugate Addition of Fluoride.

J. ORG. CHEM.

Bloom, S.; Sharber, S. A.; Holl, M. G.; Knippel, J. L.; Lectka, T.

2013, 78, 11082-11086.

2013
lightbulbmenu

2013

Origin of the Diffuse Vibrational Signature of a Cyclic Intramolecular Proton Bond: Anharmonic Analysis of Protonated 1,8-Disubstituted Naphthalene Ions.

J. PHYS. CHEM.

DeBlase, A. F.; Bloom, S.; Dudding, T.; Lectka, T.; Johnson, M. A. 

2013, 139, 024301.

2013
lightbulbmenu

2013

Iron(II)-Catalyzed Benzylic Fluorination.

ORG. LETT.

Bloom, S.; Pitts, C. R.; Woltornist, R.; Griswold, A.; Holl, M. G.; Lectka, T.

2013, 15, 1722-1724.

2013
lightbulbmenu

2012

Polycomponent Metal-Catalyzed Aliphatic, Allylic, and Benzylic Fluorination.

ANGEW. CHEM. INT. ED. ENGL.

Bloom, S.; Pitts, C. R.; Miller, D.; Haselton. N.; Holl, M. G.; Urheim, E.; Lectka, T. A

2012, 51, 10580-10583.

2012
lightbulbmenu

2012

Interaction of a C-F Bond with the Pi-System of a C=C Bond or ‘Head On’ with a Proximate C-H Bond.

J. ORG. CHEM.

Scerba, M. T.; Bloom, S.; Haselton, N.; Siegler, M.; Jaffe, J.; Lectka, T.

2012, 77, 1605-1609.

2012
lightbulbmenu

2012

Characterization of Highly Unusual NH+-O Hydrogen Bonding to Ester Ether Oxygen Atoms through Spectroscopic and Computational Studies.

J. PHYS. CHEM. A.

Scerba, M. T.; DeBlase, A. F.; Bloom, S.; Dudding, T.; Johnson, M. A.; Lectka, T.

2012, 116, 3556-3560

2012
lightbulbmenu

2011

Tricomponent Catalytic a,a-Difluorination of Acid Chlorides.

ORG. LETT.

Bloom, S.; Scerba, M. T.; Erb, J.; Lectka, T.
Org. Lett. 2011, 13, 5068-5071.

2011